Tag mapping. A plant of any age has thousands of tags with inconsistent naming, missing or wrong units, undocumented sign conventions and duplicates from successive control system upgrades. Establishing what each signal actually represents is unglamorous and routinely consumes more of the schedule than the modelling.
Sensor trust. Models are calibrated against instruments that drift, and a model tuned to a drifting instrument will confidently reproduce the drift. Distinguishing instrument error from process change is a prerequisite rather than a refinement, and it is one of the things a physics layer is good at, because a set of readings can be checked for mutual consistency.
Validation against operation rather than design. A model that matches the design case and has not been tested against a year of real operation, including the awkward periods, has not been validated in any useful sense.
Drift and ownership. Plants change. Setpoints move, equipment is replaced, operating strategy shifts. A twin with nobody responsible for keeping it aligned degrades quietly until it is wrong often enough to be ignored. This is usually an organisational failure rather than a technical one, and it is worth naming in the contract.
No decision attached. The most common outcome is not a wrong model. It is a correct model whose output nobody acts on, because it was never clear which decision it was meant to change.