The software in a safety function has to be justified, and the routes to justification include development to the required systematic capability, or evidence of proven use with a defined operating history and change record.
A machine learning component that adapts its own behaviour struggles with both. Systematic capability requires a development lifecycle with specification, verification and change control, and a model whose parameters move in response to data is changing without passing through that lifecycle. Proven in use requires that the thing in service is the thing that accumulated the history, and an adaptive model is not.
A model with frozen parameters, developed and verified under a proper lifecycle, treated as ordinary software, is a different proposition and does not have this problem. The distinction is whether the thing changes after it has been assessed, not whether it was built using machine learning in the first place.
That distinction is worth putting to any vendor claiming a role in a safety function: is the deployed artefact fixed, verified and under change control, and if it is, the conversation is about the assessment. If it is not, it is not a safety function component.